Abstract | OBJECTIVES: DESIGN: This was a prospective three-arm uncontrolled study with 1-year follow-up. SETTING: The setting was outpatient. PARTICIPANTS: The participants were 38 adults who had at least 3 months of symptomatic KOA and who were in the control groups of a prior prolotherapy randomized controlled trial (RCT) (Prior-Control), were ineligible for the RCT (Prior-Ineligible), or were eligible but declined the RCT (Prior-Declined). INTERVENTION: OUTCOME MEASURES: The primary outcome measure was the validated Western Ontario McMaster University Osteoarthritis Index (WOMAC). The secondary outcome measure was the Knee Pain Scale and postprocedure opioid medication use and participant satisfaction. RESULTS: The Prior-Declined group reported the most severe baseline WOMAC score (p=0.02). Compared to baseline status, participants in the Prior-Control group reported a score change of 12.4±3.5 points (19.5%, p=0.002). Prior-Decline and Prior-Ineligible groups improved by 19.4±7.0 (42.9%, p=0.05) and 17.8±3.9 (28.4%, p=0.008) points, respectively; 55.6% of Prior-Control, 75% of Prior-Decline, and 50% of Prior-Ineligible participants reported score improvement in excess of the 12-point minimal clinical important difference on the WOMAC measure. Postprocedure opioid medication resulted in rapid diminution of prolotherapy injection pain. Satisfaction was high and there were no adverse events. CONCLUSIONS:
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Authors | David Rabago, Jeffrey J Patterson, Marlon Mundt, Aleksandra Zgierska, Luke Fortney, Jessica Grettie, Richard Kijowski |
Journal | Journal of alternative and complementary medicine (New York, N.Y.)
(J Altern Complement Med)
Vol. 20
Issue 5
Pg. 383-91
(May 2014)
ISSN: 1557-7708 [Electronic] United States |
PMID | 24635447
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Complementary Therapies
(methods)
- Female
- Glucose
(administration & dosage)
- Humans
- Injections, Intra-Articular
- Male
- Middle Aged
- Osteoarthritis, Knee
(drug therapy)
- Prospective Studies
- Randomized Controlled Trials as Topic
- Sodium Morrhuate
(administration & dosage)
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