Abstract | OBJECTIVE: METHODS: We retrospectively followed a cohort of 79,166 women who were recruited to the Colon Cancer Family Registry, after exclusion of women who were relatives of a carrier of a MMR gene mutation. The Kaplan-Meier failure method was used to estimate the cumulative risk of endometrial cancer. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for association between family history of endometrial or colorectal cancer and risk of endometrial cancer. RESULTS: A total of 628 endometrial cancer cases were observed, with mean age at diagnosis of 54.4 (standard deviation: 15.7) years. The cumulative risk of endometrial cancer to age 70 years was estimated to be 0.94% (95% CI 0.83-1.05) for women with no family history of endometrial cancer, and 3.80% (95% CI 2.75-4.98) for women with at least one first- or second-degree relative with endometrial cancer. Compared with women without family history, we found an increased risk of endometrial cancer for women with at least one first- or second-degree relative with endometrial cancer (HR 3.66, 95% CI 2.63-5.08), and for women with one first-degree relative with colorectal cancer diagnosed at age <50 years (HR 1.48, 95% CI 1.15-1.91). CONCLUSION:
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Authors | Rajani Bharati, Mark A Jenkins, Noralane M Lindor, Loïc Le Marchand, Steven Gallinger, Robert W Haile, Polly A Newcomb, John L Hopper, Aung Ko Win |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 133
Issue 2
Pg. 287-92
(May 2014)
ISSN: 1095-6859 [Electronic] United States |
PMID | 24631449
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Child
- Child, Preschool
- Cohort Studies
- Colorectal Neoplasms
(genetics)
- DNA Mismatch Repair
(genetics)
- Endometrial Neoplasms
(genetics)
- Family Health
- Female
- Germ-Line Mutation
- Heterozygote
- Humans
- Infant
- Middle Aged
- Regression Analysis
- Retrospective Studies
- Young Adult
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