Relationship between the IL-4 gene promoter -590C/T (rs2243250) polymorphism and susceptibility to autoimmune diseases: a meta-analysis.

Abstract

OBJECTIVE:

Studies investigating the association between interleukin (IL)-4 gene promoter -590C/T (rs2243250) polymorphism and autoimmune diseases report conflicting results. To derive a more precise estimation of the relationship, a meta-analysis was performed.

METHODS:

A systematic literature search was conducted to identify relevant studies. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to estimate the strength of association.

RESULTS:

A total of 6001 cases and 6788 controls from 24 studies were analysed. Significant association of the C allele of IL-4 rs2243250 polymorphism with rheumatoid arthritis (RA) was detected (odds ratio (OR) = 0.696, 95% confidence interval (CI) = 0.601-0.807). Stratification by ethnicity indicated an association between the IL-4 rs2243250 polymorphism and RA in Caucasians. Furthermore, the overall ORs of the associations between the C allele and multiple scleorosis (MS) were 1.340 (95% CI = 1.102-1.630). However, we failed to reveal any association between IL-4 rs2243250 polymorphism and systemic lupus erythematosus (SLE), type 1 diabetes (T1D) or Graves' disease (GD).

CONCLUSIONS:

The present study suggests that the IL-4 rs2243250 polymorphism might be associated with genetic susceptibility to autoimmune diseases, including RA and MS.

• Authors: L-J Qiu, J Ni, H Cen, P-F Wen, M Zhang, Y Liang, H-F Pan, C Mao, D-Q Ye
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 29 Issue 1 Pg. 48-55 (Jan 2015) ISSN: 1468-3083 [Electronic] England
• PMID: 24628947 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2014 European Academy of Dermatology and Venereology.

Chemical References

• Interleukin-4

Topics

• Arthritis, Rheumatoid (ethnology, genetics)
• Autoimmune Diseases (ethnology, genetics)
• Diabetes Mellitus, Type 1 (genetics)
• Genetic Predisposition to Disease
• Graves Disease (ethnology, genetics)
• Humans
• Interleukin-4 (genetics)
• Lupus Erythematosus, Systemic (genetics)
• Multiple Sclerosis (genetics)
• Polymorphism, Single Nucleotide
• Promoter Regions, Genetic