Numerical simulations on conformable laser-induced interstitial thermotherapy through combined use of multi-beam heating and biodegradable nanoparticles.

Abstract

Clinically, precisely heating and thus completely ablating diseased tumor tissue through laser beam is still facing many technical challenges. In this study, numerical simulation of a conformal heating modality based on multi-beam laser along with biodegradable magnesium nanoparticles (Mg-NPs) was put forward to treat liver tumor with large size or irregular shape. Further, a Gaussian-like distribution was proposed to investigate the influence of Mg-NP deposition on the nanoenhanced laser-induced interstitial thermotherapy (LITT). A temperature feedback system was adopted to control the temperature range to avoid overheating. To preliminarily validate the heating enhancement induced by the applied multi-beam laser and Mg-NPs, a conceptual experiment was performed. Both theoretical simulation and experimental measurements demonstrated that multi-beam laser with Mg-NPs could improve efficiency in the conformal heating of tumors with irregular shape or large size. In addition, the distribution and content of Mg-NPs produced significant impact on thermotherapy: (1) The adjustable parameter σ in the Gaussian-like distribution could reflect various practical situations and diffusivities of Mg-NPs; (2) under the premise of the same concentration of Mg-NPs and short time to heat a small-sized target, the whole liver tumor containing Mg-NPs could not improve the efficiency as the nanoparticles limited the photons to be absorbed only around the fibers, while liver tumor partially containing Mg-NPs could improve the thermotherapy efficiency up to 20 %; and (3) the addition of Mg-NPs was rather beneficial for realizing a conformal heating as the residual thermal energy was much less than that without Mg-NPs. This study suggests a feasible and promising modality for planning a high-performance LITT in future clinics.

• Authors: Jie Zhang, Chao Jin, Zhi-Zhu He, Jing Liu
• Journal: Lasers in medical science (Lasers Med Sci) Vol. 29 Issue 4 Pg. 1505-16 (Jul 2014) ISSN: 1435-604X [Electronic] England
• PMID: 24627283 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Computer Simulation
• Humans
• Hyperthermia, Induced (methods)
• Liver Neoplasms (therapy)
• Models, Biological
• Nanoparticles (therapeutic use)