Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: RESULTS: Microalbuminuria (UACR ≥30 mg/g) was present in fewer than 2% at either study visit. After multivariate adjustments, there was no cross-sectional association between UACR and any measure of insulin sensitivity. Neither OGIS nor HOMA-IR was significantly associated with follow-up UACR, but in a multivariate regression analysis, baseline M/I emerged as an independent predictor of UACR at follow-up (β-coefficient -0.14; P = 0.001). CONCLUSIONS: In healthy middle-aged adults, reduced insulin sensitivity, assessed by hyperinsulinemic-euglycemic clamp, is continuously associated with a greater risk of increasing albuminuria. This finding suggests that reduced insulin sensitivity either is simply related to or might causally contribute to the initial pathogenesis of albuminuria.
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Authors | Stefan Pilz, Femke Rutters, Giel Nijpels, Coen D A Stehouwer, Kurt Højlund, John J Nolan, Beverley Balkau, Jacqueline M Dekker, RISC Investigators |
Journal | Diabetes care
(Diabetes Care)
Vol. 37
Issue 6
Pg. 1597-603
(Jun 2014)
ISSN: 1935-5548 [Electronic] United States |
PMID | 24623021
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 by the American Diabetes Association. |
Chemical References |
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Topics |
- Adult
- Albuminuria
(epidemiology, physiopathology)
- Cardiovascular Diseases
(epidemiology)
- Creatinine
(urine)
- Cross-Sectional Studies
- Europe
(epidemiology)
- Female
- Follow-Up Studies
- Glucose Clamp Technique
- Glucose Tolerance Test
- Humans
- Hyperinsulinism
(diagnosis)
- Incidence
- Insulin
(metabolism)
- Insulin Resistance
- Insulin Secretion
- Male
- Middle Aged
- Multivariate Analysis
- Prospective Studies
- Risk Factors
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