Abstract | INTRODUCTION: Currently liver biopsy represents the gold standard to assess severity and fibrosis grade in liver diseases. Since this laborious, costly, and invasive procedure is associated with possible complications, non-invasive methods and biomarkers, which allow for an easy, reliable, and repeatable assessment of liver disease are warranted. Cytokeratin (CK) 18 is an intermediary filament protein, expressed in hepatocytes, which is proteolytically cleaved during liver damage. The resultant CK-18 fragments are released by hepatocytes and can be detected in serum. METHODS: A selective literature search in PubMed for original publications about the detection of CK-18 cell death markers in liver diseases was undertaken. RESULTS: DISCUSSION: Due to promising results of various studies, CK-18 cell death markers could be applied in clinical routine soon.
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Authors | A Canbay, A Feldstein, B Kronenberger, K Schulze-Osthoff, H Bantel |
Journal | Zeitschrift fur Gastroenterologie
(Z Gastroenterol)
Vol. 52
Issue 3
Pg. 290-5
(Mar 2014)
ISSN: 1439-7803 [Electronic] Germany |
Vernacular Title | Zytokeratin-18 als Marker zur nichtinvasiven Diagnostik und Prognose akuter und chronischer Lebererkrankungen. |
PMID | 24622872
(Publication Type: English Abstract, Journal Article, Meta-Analysis, Review)
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Copyright | © Georg Thieme Verlag KG Stuttgart · New York. |
Chemical References |
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Topics |
- Acute Disease
- Biomarkers
(blood)
- Chronic Disease
- Humans
- Keratin-18
(blood)
- Liver Diseases
(blood, diagnosis)
- Prevalence
- Reproducibility of Results
- Risk Factors
- Sensitivity and Specificity
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