[Curative effect of nasal type extranodal NK/T-cell lymphoma by sequential chemotherapy combined radiotherapy compared with chemotherapy].

Abstract

OBJECTIVE:

To explore the curative effect of nasal type extranodal NK/T-cell lymphoma by sequential chemotherapy combined radiotherapy compared with chemtherapy.

METHOD:

Fifty-seven cases of nasal type extranodal NK/T-cell lymphoma confirmed by pathological morphology and immuno-histochemistry were divided into chemotherapy combined radiotherapy group (34 cases) or chemotherapy group (23 cases). Twenty-three patients in the chemotherapy group alternately applied CHOP, VDLP and MEOP regimen after each two treatments into the clinical observation; Chemotherapy combined radiotherapy group of 34 patients, in addition to the above chemotherapy, applied three-dimensional conformal radiation therapy of the primary site by linear accelerators. Then all of patients were ceased treatment and followed up 3-5 years.

RESULT:

(1) After treatment, effective rate of two groups was 91.2% and 87.0%, there was no obvious difference (P > 0.05); After follow up about 1 year, effective rate of two groups was 76.5% and 73.9%, there was no obvious difference (P > 0.05); (3) After follow up about 3 years and 5 years, disease free survival (DFS) of two groups was 61.3%, 47.6% and 43.5%, 21.4%, there was obvious difference (P < 0.05). (4) Long-term survival is closely related to treatment mode. (5) B symptoms, advanced (III, IV) stage, the International Prognostic Index (IPI), KPS scores were correlated with prognosis, and were independent prognostic factors.

CONCLUSION:

Treatment with chemotherapy and radiotherapy for nasal type extranodal NK/T-cell lymphoma had obvious curative effect and may improve long-term survival efficiently compared with chemotherapy alone.

• Authors: Cunbang Wang, Hai Bai, Rui Xi, Yaozhu Pan, Shufen Xu, Qian Zhang, Yan Chen, Jinmao Zhou
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 27 Issue 23 Pg. 1283-6, 1290 (Dec 2013) ISSN: 2096-7993 [Print] China
• PMID: 24620654 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols
• Combined Modality Therapy
• Female
• Humans
• Lymphoma, Extranodal NK-T-Cell (drug therapy, radiotherapy, therapy)
• Male
• Middle Aged
• Radiotherapy (methods)
• Treatment Outcome
• Young Adult