A(nother) scientific strategy to prevent breast cancer in postmenopausal women by enhancing estrogen-induced apoptosis?

Abstract

The innovation of combining bazedoxifene with conjugated estrogens provides a new opportunity for women's health. The finding by the Women's Health Initiative-that the administration of conjugated equine estrogens alone to women in their 60s who have had hysterectomy results in a decrease in breast cancer incidence and a drop in mortality--was unanticipated but can now be exploited for another gain in women's health. The issue to be considered is how postmenopausal women can improve their lifestyle to take advantage of conjugated equine estrogens-alone therapy. Food and Drug Administration approval of the combination of bazedoxifene and conjugated estrogens now provides an opportunity for postmenopausal women to reduce hot flashes and to potentially selectively sensitize occult breast cancer cells to the apoptotic actions of estrogen. Clinical trials are proposed to advance women's health and to reduce the incidence of breast cancer.

• Authors: V Craig Jordan
• Journal: Menopause (New York, N.Y.) (Menopause) Vol. 21 Issue 10 Pg. 1160-4 (Oct 2014) ISSN: 1530-0374 [Electronic] United States
• PMID: 24618769 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Estrogens
• Estrogens, Conjugated (USP)
• Indoles
• Selective Estrogen Receptor Modulators
• bazedoxifene

Topics

• Aged
• Apoptosis (drug effects)
• Breast Neoplasms (pathology, prevention & control)
• Estrogens (pharmacology)
• Estrogens, Conjugated (USP) (administration & dosage, therapeutic use)
• Female
• Hot Flashes (drug therapy)
• Humans
• Hysterectomy
• Indoles (administration & dosage)
• Middle Aged
• Postmenopause
• Selective Estrogen Receptor Modulators (administration & dosage)
• Women's Health