Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients.

Abstract

Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blood glucose test when they entered the emergency department. If blood glucose was more than 11.1 mM, a GHb test was followed within 24 h. All patients were followed up for 28 days. According to diabetes mellitus (DM) history, GHb value, and outcome of follow-up, patients were divided into different groups, and mortality rates were calculated, respectively. Hyperglycemia was found in 67.44% (437/648) of patients, and 51.49% (225/437) and 48.51% (212/437) had normal and elevated GHb levels, respectively. At the end of the follow-up period, 14 of the normal GHb patients and 32 of the elevated GHb patients died (6.22 and 15.09%, respectively). In the normal GHb group, 53 had a DM history, 23 were newly diagnosed with DM, and 149 had hospital-related hyperglycemia (HRH); the mortality rates were 11.32% (6/53), 8.70% (2/23), and 4.03% (6/149), respectively. In the elevated GHb group, 114 had a DM history, 83 were newly diagnosed with DM, and 15 had HRH; the mortality rates were 13.16% (15/114), 19.27% (16/83), and 6.67% (1/15), respectively. Hyperglycemia and GHb might play important roles in the prognosis and assessment for critical patients, and the prognosis would vary according to the different causes of hyperglycemia.

• Authors: Z L Zhang, X M Che, Z H Bai, W J Bu, L Bai, H H Pei
• Journal: Genetics and molecular research : GMR (Genet Mol Res) Vol. 13 Issue 3 Pg. 7006-12 (Jan 24 2014) ISSN: 1676-5680 [Electronic] Brazil
• PMID: 24615078 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Glycated Hemoglobin A

Topics

• Aged
• Aged, 80 and over
• Blood Glucose (metabolism)
• Critical Illness
• Diabetes Mellitus (blood, diagnosis)
• Female
• Follow-Up Studies
• Glycated Hemoglobin (metabolism)
• Humans
• Hyperglycemia (blood, diagnosis)
• Male
• Middle Aged
• Prognosis
• Risk Assessment (methods, statistics & numerical data)
• Risk Factors
• Time Factors