Abstract |
MicroRNAs have recently emerged as key regulators of gastric cancers. Here we found that miR-145, miR-133a and miR-133b were down-regulated in gastric cancer tissues and cell lines. Overexpression of miR-145, miR-133a and miR-133b induced G1 cell cycle arrest and inhibited cell proliferation, migration and invasion in vitro. MiR-145, miR-133a and miR-133b targeted the transcription factor SP1, knockdown of which reduced the expression of MMP-9 and Cyclin D1 that were involved in cell growth and invasion. Thus, our findings demonstrated for the first time that miR-145, miR-133a and miR-133b suppressed the proliferation, migration, invasion and cell cycle progression of gastric cancer cells through decreasing expression of Sp1 and its downstream proteins.
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Authors | Tianzhu Qiu, Xin Zhou, Jian Wang, Yiping Du, Jun Xu, Zebo Huang, Wei Zhu, Yongqian Shu, Ping Liu |
Journal | FEBS letters
(FEBS Lett)
Vol. 588
Issue 7
Pg. 1168-77
(Apr 02 2014)
ISSN: 1873-3468 [Electronic] England |
PMID | 24613927
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- 3' Untranslated Regions
- MIRN133 microRNA, human
- MIRN145 microRNA, human
- MicroRNAs
- Sp1 Transcription Factor
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Topics |
- 3' Untranslated Regions
- Binding Sites
- Cell Cycle Checkpoints
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Down-Regulation
- Gene Expression Regulation, Neoplastic
- Humans
- MicroRNAs
(genetics)
- Neoplasm Invasiveness
- RNA Interference
- Sp1 Transcription Factor
(genetics, metabolism)
- Stomach Neoplasms
(genetics, metabolism, pathology)
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