Abstract | CONTEXT: OBJECTIVE: SUBJECT AND METHODS: RESULTS:
Apo C-II protein was detected in the serum by immunoprecipitation and Western blotting. Large amounts of IgG and IgM were incorporated with apo C-II protein coimmunoprecipitated by anti- apo C-II antibody. IgG, but not IgM, purified from the serum prevented interaction of apo C-II with lipid substrate and diminished LPL hydrolysis activity. CONCLUSION: We identified anti- apo C-II antibody in a myeloma-unrelated severe hypertriglyceridemic patient. In vitro analysis confirmed that the autoantibody disrupted the interaction between apo C-II and lipid substrate, suggesting the etiological role of anti- apo C-II antibody in severe hypertriglyceridemia in this patient.
|
Authors | Hiroyasu Yamamoto, Minoru Tanaka, Satomi Yoshiga, Tohru Funahashi, Iichiro Shimomura, Shinji Kihara |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 99
Issue 5
Pg. 1525-30
(May 2014)
ISSN: 1945-7197 [Electronic] United States |
PMID | 24606081
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Apolipoprotein C-II
- Autoantibodies
- apolipoprotein C-II (St Michael)
|
Topics |
- Adult
- Apolipoprotein C-II
(immunology)
- Autoantibodies
(blood)
- Autoimmune Diseases
(blood, immunology)
- Female
- Humans
- Hypertriglyceridemia
(blood, immunology)
|