Skin necrosis: a rare complication of protein S deficiency.

Abstract

Hereditary protein S deficiency is an autosomal dominant disorder leading to recurrent venous thrombosis and, less commonly, to arterial thrombosis. Cases of skin necrosis have been documented in patients with protein C or S deficiency while being treated with warfarin. We describe herein a patient with protein S deficiency who developed significant skin necrosis without being exposed to warfarin. She had a protracted clinical course resulting in gangrene and transmetatarsal amputation. Recognition of this rare complication and an earlyhematology referral may prevent dismal outcomes in patients with protein S deficiency.

• Authors: Ashif Jethava, Thalia Mesologites, Syed Ali, Constantin A Dasanu
• Journal: Connecticut medicine (Conn Med) Vol. 78 Issue 1 Pg. 29-32 (Jan 2014) ISSN: 0010-6178 [Print] United States
• PMID: 24600778 (Publication Type: Case Reports, Journal Article)

Chemical References

• Protein C

Topics

• Female
• Humans
• Ischemic Attack, Transient (complications, epidemiology)
• Middle Aged
• Necrosis
• Protein C (analysis)
• Protein S Deficiency (complications, epidemiology)
• Skin (pathology)
• Skin Diseases, Vesiculobullous (epidemiology, etiology)
• Smoking (epidemiology)