Inflammation is part of the body's immune response in order to remove harmful stimuli-like pathogens, irritants or damaged cells-and start the healing process. Recurrent or chronic
inflammation on the other side seems a predisposing factor for
carcinogenesis and has been found associated with
cancer development. In
chronic pancreatitis mutations of the cationic
trypsinogen (PRSS1) gene have been identified as risk factors of the disease.
Hereditary pancreatitis (HP) is a rare cause of chronic pancreatic
inflammation with an early onset, mostly during childhood. HP often starts with recurrent episodes of
acute pancreatitis and the clinical phenotype is not very much different from other etiologies of the disease. The long-lasting
inflammation however generates a
tumor promoting environment and represents a major risk factor for
tumor development This review will reflect our knowledge concerning the specific risk of HP patients to develop
pancreatic cancer.