IL-17A is elevated in sera of patients with poorly differentiated ovarian papillary serous cystadenocarcinoma.

Abstract

BACKGROUND:

IL-17A a member of IL-17 family of cytokines is an inflammatory cytokine produced by a subset of CD4+ T cells that links innate and adaptive immunity. IL-17A has been shown to be a key mediator of inflammation in autoimmune diseases, transplant rejection and cancers.

OBJECTIVE:

To investigate the level of IL-17A in sera of southern Iranian patients with papillary serous cystadenocarcinoma of ovary and compare it with age-matched women of the same region.

METHODS:

In this study we investigated IL-17A and CA125 levels in sera of 26 patients with ovarian serous cystadenocarcinoma and 62 healthy age matched women by commercial ELISA assays.

RESULTS:

Fifteen (58%) and 16 (61.5%) out of 26 patients showed elevated IL-17A (1.25 ± 2.25 pg/ml) and CA125 (218 ± 224.69 IU/ml) in their sera, respectively. No healthy individual had detectable IL-17A or elevated CA125 in their sera (8.85 ± 2.86 IU/ml). The mean IL-17A levels in poorly differentiated tumors (3.33 ± 2.36 pg/ml) was significantly higher than that of well differentiated (0.14 ± 0.38 pg/ml) and moderately differentiated (undetectable) tumors. There was also a positive correlation between IL-17A and CA125 in sera of patients and controls when grouped together (r=0.37, p=0.005).

CONCLUSION:

Elevation of IL-17A in a high percentage of ovarian serous cystadenocarcinoma and lack of this cytokine in healthy individuals makes it a specific candidate in diagnosis, follow up or immunotherapy.

• Authors: Mahyar Malekzadeh, Alamtaj Samsami Dehaghani, Abbas Ghaderi, Mehrnoosh Doroudchi
• Journal: Cancer biomarkers : section A of Disease markers (Cancer Biomark) Vol. 13 Issue 6 Pg. 417-25 (Jan 01 2013) ISSN: 1875-8592 [Electronic] Netherlands
• PMID: 24595078 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• CA-125 Antigen
• Interleukin-17

Topics

• Adult
• Aged
• Biomarkers, Tumor (blood)
• CA-125 Antigen (blood)
• Carcinoma, Ovarian Epithelial
• Case-Control Studies
• Cell Differentiation (physiology)
• Cohort Studies
• Cystadenocarcinoma, Serous (blood, pathology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Interleukin-17 (blood)
• Middle Aged
• Neoplasms, Glandular and Epithelial (blood, pathology)
• Ovarian Neoplasms (blood, pathology)
• Young Adult