HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Induction of epoxide hydrolase, glucuronosyl transferase, and sulfotransferase by phenethyl isothiocyanate in male Wistar albino rats.

Abstract
Phenethyl isothiocyanate (PEITC) is an isothiocyanate found in watercress as the glucosinolate (gluconasturtiin). The isothiocyanate is converted from the glucosinolate by intestinal microflora or when contacted with myrosinase during the chopping and mastication of the vegetable. PEITC manifested protection against chemically-induced cancers in various tissues. A potential mechanism of chemoprevention is by modulating the metabolism of carcinogens so as to promote deactivation. The principal objective of this study was to investigate in rats the effect of PEITC on carcinogen-metabolising enzyme systems such as sulfotransferase (SULT), N-acetyltransferase (NAT), glucuronosyl transferase (UDP), and epoxide hydrolase (EH) following exposure to low doses that simulate human dietary intake. Rats were fed for 2 weeks diets supplemented with PEITC at 0.06 µmol/g (low dose, i.e., dietary intake), 0.6 µmol/g (medium dose), and 6.0 µmol/g (high dose), and the enzymes were monitored in rat liver. At the Low dose, no induction of the SULT, NAT, and EH was noted, whereas UDP level was elevated. At the Medium dose, only SULT level was increased, whereas at the High dose marked increase in EH level was observed. It is concluded that PEITC modulates carcinogen-metabolising enzyme systems at doses reflecting human intake thus elucidating the mechanism of its chemoprevention.
AuthorsAhmad Faizal Abdull Razis, Noramaliza Mohd Noor, Nattaya Konsue
JournalBioMed research international (Biomed Res Int) Vol. 2014 Pg. 391528 ( 2014) ISSN: 2314-6141 [Electronic] United States
PMID24592387 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Isothiocyanates
  • phenethyl isothiocyanate
  • Acetyltransferases
  • Glucuronosyltransferase
  • Sulfotransferases
  • Epoxide Hydrolases
Topics
  • Acetyltransferases (metabolism)
  • Animals
  • Enzyme Induction (drug effects)
  • Epoxide Hydrolases (biosynthesis)
  • Glucuronosyltransferase (biosynthesis)
  • Humans
  • Isothiocyanates (pharmacology)
  • Liver (drug effects, enzymology)
  • Male
  • Rats, Wistar
  • Sulfotransferases (biosynthesis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: