Abstract |
One hundred and four patients with acute leukemia treated by allogeneic bone marrow transplantation in Japan were analysed for the incidence of interstitial pneumonitis (IP). Thirty-six (35%) of 104 marrow graft recipients developed IP. Cytomegalovirus (CMV) was the most frequent organism (61%). Using multivariate analysis, remission at transplant (P = 0.0001) and use of cyclosporin A to prevent graft-versus-host disease (P = 0.0363) were found to be significant factors associated with a decreased incidence of IP. For preventing IP, anti-CMV hyperimmune globulin was effective, while interferon and acyclovir were not.
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Authors | H Teshima, T Masaoka, T Inoue, S Kato, K Naito, T Mori, A Kanamaru, Y Saito, M Ohira, Y Moriyama |
Journal | Bone marrow transplantation
(Bone Marrow Transplant)
Vol. 1
Issue 2
Pg. 179-83
(Dec 1986)
ISSN: 0268-3369 [Print] England |
PMID | 2458786
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immune Sera
- Immunoglobulins
- Immunoglobulins, Intravenous
- cytomegalovirus-specific hyperimmune globulin
- Interferons
- Acyclovir
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Topics |
- Acyclovir
(therapeutic use)
- Adolescent
- Adult
- Bone Marrow Transplantation
- Child
- Child, Preschool
- Female
- Humans
- Immune Sera
(administration & dosage)
- Immunoglobulins
- Immunoglobulins, Intravenous
- Interferons
(therapeutic use)
- Japan
- Leukemia, Myeloid, Acute
(complications, surgery)
- Male
- Middle Aged
- Patient Isolation
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(complications, surgery)
- Pulmonary Fibrosis
(epidemiology, etiology, mortality)
- Transplantation, Homologous
(adverse effects)
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