Abstract | BACKGROUND: OBJECTIVE: METHODS: Electrophysiological parameters and adenosine sensitivity of retrograde fast pathway were studied in 21 consecutive patients (18 women; mean age 57 ± 10 years) with slow-fast AVNRT and 24 patients (11 women; mean age 46 ± 16 years) as the control group. RESULTS: Fifteen (71%) patients with AVNRT and 18 (75%) patients in the control group developed transient ventriculoatrial (VA) block after the intravenous administration of adenosine (P = .79). In patients with slow-fast AVNRT, female sex (P = .003), longer VA interval during right ventricular pacing (P < .001), and longer tachycardia cycle length (P < .001) predicted transient VA block after the intravenous administration of adenosine. In patients in the control group, a shorter VA interval during fixed rate right ventricular apical pacing (P = .009) and the presence of dual atrioventricular nodal physiology (P = .002) were associated with the adenosine resistance of the retrograde fast pathway. CONCLUSIONS: The prevalence of the adenosine resistance of retrograde fast pathway's conduction is comparable between patients with and those without slow-fast AVNRT. This finding can be explained better by the existence of an insulated intranodal tract with Purkinje-like properties or a superior atrionodal connection to the nodo-Hisian region of the atrioventricular node rather than the presence of an atrio-Hisian pathway.
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Authors | Elena Efimova, Sam Riahi, Lukas Fiedler, Masahiro Esato, Philipp Sommer, Sergio Richter, Ole Breithardt, Sascha Rolf, Andreas Bollmann, Gerhard Hindricks, Arash Arya |
Journal | Heart rhythm
(Heart Rhythm)
Vol. 11
Issue 5
Pg. 871-6
(May 2014)
ISSN: 1556-3871 [Electronic] United States |
PMID | 24583097
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Arrhythmia Agents
- Adenosine
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Topics |
- Adenosine
(administration & dosage)
- Anti-Arrhythmia Agents
(administration & dosage)
- Atrioventricular Node
(drug effects, physiopathology)
- Dose-Response Relationship, Drug
- Electrocardiography
(drug effects)
- Female
- Follow-Up Studies
- Heart Rate
(drug effects)
- Humans
- Injections, Intravenous
- Male
- Middle Aged
- Prospective Studies
- Tachycardia, Atrioventricular Nodal Reentry
(drug therapy, physiopathology)
- Treatment Outcome
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