Interferons as gene activators: close linkage of two interferon-activatable murine genes.

Abstract

Previously we have identified a mouse genomic clone (clone 5) which specifies the 5' flanking region and the 5' terminal exon of an interferon-activatable gene (202 gene). Here, we show that about 5 kb upstream from this flanking region in clone 5 there occurs a 3' terminal region of a second interferon-activatable gene (203 gene). The two genes are transcribed in the same direction. Segments from the 203 gene can be hybridized to a set of five interferon-inducible RNAs. The 203 mRNAs are induced about 15-fold in interferon-treated Ehrlich ascites tumor cells.

• Authors: D A Engel, J Snoddy, E Toniato, P Lengyel
• Journal: Virology (Virology) Vol. 166 Issue 1 Pg. 24-9 (Sep 1988) ISSN: 0042-6822 [Print] United States
• PMID: 2457983 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• RNA, Messenger
• Interferons

Topics

• Animals
• Chromosome Mapping
• Cloning, Molecular
• Gene Expression Regulation
• Genes
• Genetic Linkage
• Interferons (physiology)
• Mice
• RNA, Messenger (genetics)
• Time Factors
• Transcription, Genetic
• Tumor Cells, Cultured