Abstract | OBJECTIVES: The aim of this study was to detect the frequency, time of occurrence, management and outcome of Epstein-Barr virus ( EBV) infection and related complications in pediatric renal transplant recipients. METHODS: Pediatric renal allograft recipients transplanted between August 1994 and December 2011 at our hospital was evaluated retrospectively. The patients were divided into two groups; Groups 1 and 2 were composed of patients transplanted before and after November 2007, respectively, when plasma EBV DNA levels were periodically measured. RESULTS: The study included 166 children, 89 (53.6%) boys, with a mean age of 12.2 ± 3.8 years. Prior to transplantation, 144 patients (86.7%) were EBV seropositive. Within a median follow-up period of 36 months, 11 of 22 seronegative children (50%) developed primary EBV infection. EBV reactivation was observed in 23 of 144 children (15.9%). Two patients with primary infection developed post-transplant lymphoproliferative disorder, one of whom died. Elevated serum creatinine levels or graft loss were not observed in any patient with EBV reactivation. CONCLUSIONS: EBV DNA monitoring by PCR in high-risk pediatric renal transplant recipients will provide early diagnosis and treatment of EBV infections.
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Authors | Elif Comak, Sema Akman, Gozde Ongut, Dilek Colak, Mustafa Koyun, Cagla Serpil Dogan, Derya Mutlu, Imran Saglik, Arife Uslu Gokceoglu, Ayhan Dinckan |
Journal | Renal failure
(Ren Fail)
Vol. 36
Issue 5
Pg. 760-6
(Jun 2014)
ISSN: 1525-6049 [Electronic] England |
PMID | 24575865
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Child
- Child, Preschool
- Epstein-Barr Virus Infections
(epidemiology)
- Female
- Humans
- Infant
- Kidney Function Tests
- Kidney Transplantation
- Male
- Postoperative Complications
(epidemiology, microbiology)
- Recurrence
- Retrospective Studies
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