High-frequency percussive ventilation in severe acute respiratory distress syndrome: A single center experience.

Abstract

BACKGROUND:

Few studies have investigated high-frequency percussive ventilation (HFPV) in adult patients with acute respiratory distress syndrome (ARDS).

MATERIALS AND METHODS:

We retrospectively analyzed data from critically ill-patients with moderate and severe ARDS who received HFPV. Ventilation and oxygenation were governed according to a predefined protocol. HFPV was continued until patients could be switched to conventional ventilation.

RESULTS:

A total of 42 patients (20 with pneumonia-related ARDS and 22 non-septic ARDS cases) were evaluable. Baseline demographic characteristics, severity of illness, lung injury score; pH and respiratory variables were comparable between pneumonia and non-sepsis-related ARDS. Within 24 h, HFPV restored normal pH and PaCO2 and considerably improved oxygenation. Oxygenation improved more in non-septic than in pneumonia-related ARDS. Patients with pneumonia-induced ARDS also remained longer HFPV-dependent (7.0 vs. 4.9 days; P < 0.05). Mortality at 30 days was significantly higher in pneumonia-related than in non-sepsis-related ARDS (50% vs. 18%; P = 0.01).

CONCLUSIONS:

HFPV caused rapid and sustained improvement of oxygenation and ventilation in patients with moderate to severe ARDS. Less improved oxygenation, longer ventilator dependency and worse survival were observed in pneumonia-related ARDS.

• Authors: Herbert Spapen, Marianne Borremans, Marc Diltoer, Viola Van Gorp, Duc Nam Nguyen, Patrick M Honoré
• Journal: Journal of anaesthesiology, clinical pharmacology (J Anaesthesiol Clin Pharmacol) Vol. 30 Issue 1 Pg. 65-70 (Jan 2014) ISSN: 0970-9185 [Print] India
• PMID: 24574596 (Publication Type: Journal Article)