Abstract | OBJECTIVE: STUDY DESIGN: Forty tongue cancer specimens were immunohistochemically examined for COX-2 and VEGF-C expression and for lymphatic vessel density (LVD). We analyzed the relationships between COX-2 and VEGF-C expression and the relationships of such expression with clinicopathologic findings and survival of patients. RESULTS: Eighteen tumors out of 40 (45%) showed COX-2 expression, and 18 tumors (45%) expressed VEGF-C. Twelve tumors (30%) coexpressed COX-2/ VEGF-C. A significant correlation was found between COX-2 and VEGF-C expression (P < .01). Of note, COX-2/ VEGF-C coexpression significantly correlated with lymphangiogenesis, LNM, TNM stage (P < .01), and LVD (P < .05). In Cox regression for survival, COX-2/ VEGF-C coexpression was identified as an independent prognostic factor (P < .05). CONCLUSIONS: Our results suggest that examination of immunohistochemical expression of COX-2 and VEGF-C predicts LNM and survival in human oral tongue cancers.
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Authors | Yoshihiro Morita, Nobuo Morita, Kenji Hata, Masako Nakanishi, Natsuko Kimoto, Tetsuji Omata, Yasushi Nakamura, Toshiyuki Yoneda |
Journal | Oral surgery, oral medicine, oral pathology and oral radiology
(Oral Surg Oral Med Oral Pathol Oral Radiol)
Vol. 117
Issue 4
Pg. 502-10
(Apr 2014)
ISSN: 2212-4411 [Electronic] United States |
PMID | 24560404
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Vascular Endothelial Growth Factor C
- Cyclooxygenase 2
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Topics |
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
(metabolism, pathology)
- Cyclooxygenase 2
(metabolism)
- Female
- Humans
- Immunoenzyme Techniques
- Lymphangiogenesis
(physiology)
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Grading
- Neoplasm Staging
- Prognosis
- Survival Analysis
- Tongue Neoplasms
(metabolism, pathology)
- Vascular Endothelial Growth Factor C
(metabolism)
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