HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a (10)BSH-containing WOW emulsion.

Abstract
A 63-year-old man with multiple HCC in his left liver lobe was enrolled as the first patient in a pilot study of boron neutron capture therapy (BNCT) involving the selective intra-arterial infusion of a (10)BSH-containing water-in-oil-in-water emulsion ((10)BSH-WOW). The size of the tumorous region remained stable during the 3 months after the BNCT. No adverse effects of the BNCT were observed. The present results show that (10)BSH-WOW can be used as novel intra-arterial boron carriers during BNCT for HCC.
AuthorsHironobu Yanagie, Syushi Higashi, Koji Seguchi, Ichiro Ikushima, Mituteru Fujihara, Yasumasa Nonaka, Kazuyuki Oyama, Syoji Maruyama, Ryo Hatae, Minoru Suzuki, Shin-ichiro Masunaga, Tomoko Kinashi, Yoshinori Sakurai, Hiroki Tanaka, Natsuko Kondo, Masaru Narabayashi, Tetsuya Kajiyama, Akira Maruhashi, Koji Ono, Jun Nakajima, Minoru Ono, Hiroyuki Takahashi, Masazumi Eriguchi
JournalApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 88 Pg. 32-7 (Jun 2014) ISSN: 1872-9800 [Electronic] England
PMID24559940 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Borohydrides
  • Emulsions
  • Oils
  • Sulfhydryl Compounds
  • Water
  • mercaptoundecahydrododecaborate
Topics
  • Borohydrides (administration & dosage, chemistry)
  • Boron Neutron Capture Therapy (methods)
  • Carcinoma, Hepatocellular (diagnosis, radiotherapy)
  • Emulsions (administration & dosage, chemistry)
  • Humans
  • Injections, Intra-Arterial
  • Liver Neoplasms (diagnosis, radiotherapy)
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local (diagnosis, radiotherapy)
  • Oils (chemistry)
  • Pilot Projects
  • Sulfhydryl Compounds (administration & dosage, chemistry)
  • Treatment Outcome
  • Water (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: