Subset of natural killer cells is induced by immune complexes to display Fc receptors for IgE and IgA and demonstrates isotype regulatory function.

Abstract

Expression of Fc receptors for IgE (FcER) or IgA (FcAR) on purified natural killer (NK) cells was investigated. No FcER+ and a few FcAR+ NK cells were detectable on freshly separated NK (NKH-1+) cells from normal donors. Incubation of NK cells with IgE-anti-IgE immune complexes or IgA-anti-IgA immune complexes induced up to 10 and 20% FcER+ or FcAR+ cells, respectively. These FcR were induced on CD3- but not on CD3+ NKH-1+ cells. In contrast, NK cells from patients with various dysgammaglobulinemias could not be induced to express FcER or FcAR corresponding to their abnormal circulating IgE and/or IgA levels. Enriched FcER+ or FcAR+ induced NK cell supernatants from normals enhanced IgE or IgA synthesis from Ig secreting B cell lines in an isotype-specific fashion without increasing proliferation. Thus NK cells, after interaction with specific Ig isotypes in complexes, express FcR and produce differentiation factors for that isotype.

• Authors: H Kimata, A Saxon
• Journal: The Journal of clinical investigation (J Clin Invest) Vol. 82 Issue 1 Pg. 160-7 (Jul 1988) ISSN: 0021-9738 [Print] United States
• PMID: 2455732 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigen-Antibody Complex
• Antigens, CD
• Fc(alpha) receptor
• Immunoglobulin A
• Immunoglobulin Isotypes
• Receptors, Fc
• Receptors, IgE
• Immunoglobulin E
• RNA

Topics

• Antibody Specificity
• Antigen-Antibody Complex (physiology)
• Antigens, CD
• B-Lymphocytes (metabolism)
• Blood Protein Disorders (metabolism)
• Cell Line
• Humans
• Immunoglobulin A (biosynthesis, metabolism)
• Immunoglobulin E (biosynthesis, metabolism)
• Immunoglobulin Isotypes (physiology)
• Killer Cells, Natural (classification, immunology, metabolism)
• Lymphocyte Activation
• Protein Biosynthesis
• RNA (biosynthesis)
• Receptors, Fc (biosynthesis)
• Receptors, IgE