A novel nano-carrier transdermal gel against inflammation.

Abstract

The objective was to develop a stable, reproducible and patient non-infringing novel transdermal drug delivery system "nano-carrier transdermal gel" (NCTG) in combination of partial dose replacement of diclofenac diethylamine (DDEA) by curcumin (CRM). The drug content of gel was 99.30 and 97.57% for DDEA and CRM. Plasma samples were analyzed by liquid chromatography with triple-quadrupole tandem mass spectrometer (LC-MS/MS). Data were integrated with Analyst™ and analyzed by WinNonlin; stability parameters were analyzed using Tukey-Kramer multiple comparison test. Its average skin irritation scored 0.49 concluded to be non-irritant, safe for human use and in vivo studies revealed significantly greater extent of absorption and highly significant inhibition (%) of carrageenan induced paw edema. The results also demonstrated that encapsulation of drugs in nano-carrier increases its biological activity due to superior skin penetration potential. Hence, a novel once day transdermal gel of nano-carrier (nano-transfersomes; deformable vesicular) is achieved, to increase systemic availability, subsequent reduction in dose and toxicity of DDEA was developed for the treatment of inflammation.

• Authors: Hema Chaudhary, Kanchan Kohli, Vikash Kumar
• Journal: International journal of pharmaceutics (Int J Pharm) Vol. 465 Issue 1-2 Pg. 175-86 (Apr 25 2014) ISSN: 1873-3476 [Electronic] Netherlands
• PMID: 24548719 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Acrylates
• Anti-Inflammatory Agents
• Drug Carriers
• Drug Combinations
• Gels
• Diclofenac
• Carrageenan
• Curcumin
• carbopol 934P

Topics

• Acrylates (chemistry)
• Administration, Cutaneous
• Animals
• Anti-Inflammatory Agents (administration & dosage, blood, chemistry, pharmacokinetics, toxicity)
• Biological Availability
• Carrageenan
• Chemistry, Pharmaceutical
• Chromatography, Liquid
• Curcumin (administration & dosage, chemistry, pharmacokinetics, toxicity)
• Diclofenac (administration & dosage, blood, chemistry, pharmacokinetics, toxicity)
• Disease Models, Animal
• Drug Administration Schedule
• Drug Carriers
• Drug Combinations
• Drug Stability
• Gels
• Inflammation (chemically induced, prevention & control)
• Male
• Nanoparticles
• Nanotechnology
• Rats, Wistar
• Skin (drug effects, pathology)
• Skin Irritancy Tests
• Tandem Mass Spectrometry
• Technology, Pharmaceutical (methods)