Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study.

Abstract

RATIONALE:

Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV₁ < LLN.

METHODS:

Nested case-control study of WTC-exposed firefighters. Cases had FEV₁ < LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured.

RESULTS:

LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV₁ < LLN in a multivariable model.

CONCLUSIONS:

Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV₁ < LLN.

• Authors: Jun Tsukiji, Soo Jung Cho, Ghislaine C Echevarria, Sophia Kwon, Phillip Joseph, Edward J Schenck, Bushra Naveed, David J Prezant, William N Rom, Ann Marie Schmidt, Michael D Weiden, Anna Nolan
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 19 Issue 2 Pg. 159-65 (Mar 2014) ISSN: 1366-5804 [Electronic] England
• PMID: 24548082 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• APOA1 protein, human
• Apolipoprotein A-I
• Biomarkers
• Lysophospholipids
• Particulate Matter
• lysophosphatidic acid

Topics

• Adult
• Apolipoprotein A-I (blood)
• Biomarkers (blood)
• Case-Control Studies
• Firefighters
• Forced Expiratory Volume
• Humans
• Lung Injury (blood, etiology, physiopathology)
• Lysophospholipids (blood)
• Middle Aged
• Occupational Exposure
• Particulate Matter (toxicity)
• Risk
• September 11 Terrorist Attacks