Immunogenic potential of tumor cells after treatment with antitumor chemotherapeutic agents.

Abstract

Mouse EL-4 lymphoma cells exposed in vitro for short periods to 4-hydroperoxycyclophosphamide, an in vitro active derivative of cyclophosphamide, and to another alkylating agent, cis-diamminedichloroplatinum(II), as well as to mitomycin C, induced development of antitumor immunity in syngeneic mice co-administered with OK-432, an immunostimulator prepared from streptococci. The anthracyclines (adriamycin and daunomycin) were very slightly effective. The efficacy of the alkylating agents in inducing tumor immunity was also demonstrated by their ability to stimulate secondary in vitro generation of splenic cytotoxicity. These data supported the proposed explanation for effectiveness of chemoimmunotherapy against poorly immunogenic tumors.

• Authors: T Ujiie
• Journal: The Japanese journal of experimental medicine (Jpn J Exp Med) Vol. 58 Issue 1 Pg. 33-8 (Feb 1988) ISSN: 0021-5031 [Print] Japan
• PMID: 2454340 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antineoplastic Agents
• Mitomycins
• Nitrosourea Compounds
• Nimustine
• Bleomycin
• Mitomycin
• Doxorubicin
• Cyclophosphamide
• Cisplatin
• perfosfamide
• Daunorubicin

Topics

• Adjuvants, Immunologic (pharmacology)
• Animals
• Antineoplastic Agents (pharmacology)
• Bleomycin (pharmacology)
• Cisplatin (pharmacology)
• Cyclophosphamide (analogs & derivatives, pharmacology)
• Cytotoxicity, Immunologic
• Daunorubicin (pharmacology)
• Doxorubicin (pharmacology)
• Female
• Immunity, Innate
• Immunization
• Mice
• Mice, Inbred C57BL
• Mitomycin
• Mitomycins (pharmacology)
• Neoplasm Transplantation
• Nimustine
• Nitrosourea Compounds (pharmacology)
• Spleen (immunology, pathology)
• Thymoma (immunology, pathology)
• Tumor Cells, Cultured (drug effects, immunology, transplantation)