Abstract | AIMS: MAIN METHODS: Bilateral guide cannulae were implanted to allow intra-CA1 microinjections. KEY FINDINGS: Data showed that mice with 10 and 20 days of swimming, only acquired the emotional memory, while 30 days of swimming exercise improved it. On the other hand, pretest intra-CA1 injection of scopolamine at the doses of 2 and 3 but not 1 μg/mouse reduced the emotional memory. Our results demonstrated that 20 days of swimming by itself and without any drug injection restored the emotional memory deficit induced by intra-CA1 injection of scopolamine, only at the dose of 2 but not 3 μg/mouse. Moreover, once daily injection of the subthreshold doses of morphine (2.5 and 5 mg/kg, i.p.) during the last 7 days of the 20 day-swimming intervention, improved the emotional memory deficit induced by scopolamine (3 μg/mouse) and this effect could be blocked by the subthreshold doses of naloxone (0.2 and 0.4 mg/kg). It was noted that all previous interventions did not alter the anxiety-like behaviors. SIGNIFICANCE: Swimming improved the emotional memory by itself and restored the emotional memory deficit induced by the intra-CA1 injection of scopolamine. Mu opioid receptor-dependent mechanism(s) is(are) suggested to play a role in this phenomenon.
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Authors | Mohammad Nasehi, Maryam Nasehi, Farhad Rahmani-Nia, Bahman Mirzaei, Mohammad Torabi-Nami, Mohammad-Reza Zarrindast |
Journal | Physiology & behavior
(Physiol Behav)
Vol. 128
Pg. 237-46
(Apr 10 2014)
ISSN: 1873-507X [Electronic] United States |
PMID | 24534175
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Receptors, Opioid, mu
- Naloxone
- Morphine
- Scopolamine
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Topics |
- Animals
- Emotions
(drug effects, physiology)
- Exploratory Behavior
(drug effects, physiology)
- Male
- Memory Disorders
(chemically induced, physiopathology)
- Mice
- Morphine
(pharmacology)
- Naloxone
(pharmacology)
- Physical Exertion
(physiology)
- Receptors, Opioid, mu
(agonists, antagonists & inhibitors, drug effects, physiology)
- Scopolamine
(pharmacology)
- Swimming
(physiology)
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