Flurbiprofen in rapid eye movement sleep deprivation induced hyperalgesia.

Abstract

BACKGROUND:

Rapid eye movement (REM) sleep deprivation induces hyperalgesia in healthy rats. Here, we evaluated the effects of flurbiprofen, an anti-inflammatory and neuroprotective agent, on the increased thermal responses observed in REM sleep deprived rats.

METHODS:

Forty female rats were divided into four groups following 96-hour REM sleep deprivation: intraperitoneal injections of placebo, and flurbiprofen 5 mg/kg, 15 mg/kg and 40 mg/kg were made in CONT (n=10), FBP5, FBP15 and FBP40 groups respectively. Pain threshold measurements were performed three times at baseline (0.hour), at the end of REM sleep deprivation (96.hour) and at 1 h after injections (97.hour) by hot plate and tail-flick tests.

RESULTS:

REM sleep deprivation induced a significant decrease in pain thresholds of all rats (hotplate: 0.hour vs 96.hour, 9.75±2.85 vs 5.10±2.02, p<0.001; tail flick: 0.hour vs 96.hour, 11.92±4.62 vs 7.92±5.15, p<0.001). Flurbiprofen in 15 mg/kg and 40 mg/kg doses significantly improved pain tolerance measured by tail flick test (tail flick in FBP15 and FBP40 groups: 96.hour vs 97.hour, 7.01±4.97 vs 8.34±3.61 and 5.06±1.57 vs 7.04±2.49, p<0.05 for both).

CONCLUSION:

96 h of REM sleep deprivation resulted in reduced pain thresholds in both hot plate and tail flick tests. Flurbiprofen was used for the first time in a rat model of REM sleep deprivation, and it provided anti-nociceptive effects in 15 mg/kg and 40 mg/kg doses. Flurbiprofen may have the potential for treatment of painful syndromes accompanying insomnia or sleep loss.

• Authors: Elif Ezgi Gürel, Keremcan Ural, Gülnur Öztürk, Levent Öztürk
• Journal: Physiology & behavior (Physiol Behav) Vol. 128 Pg. 155-8 (Apr 10 2014) ISSN: 1873-507X [Electronic] United States
• PMID: 24534174 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Analgesics
• Flurbiprofen

Topics

• Analgesics (therapeutic use)
• Animals
• Dose-Response Relationship, Drug
• Female
• Flurbiprofen (therapeutic use)
• Hot Temperature
• Hyperalgesia (etiology, physiopathology)
• Pain Threshold (drug effects)
• Rats
• Rats, Sprague-Dawley
• Sleep Deprivation (complications, physiopathology)