Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline.

Abstract

We describe the case of a 63-year-old female who presented with severe inflammatory spondylitis, refractory to various antibiotics. Mycobacterial and fungal osteomyelitis were unlikely. Although asymptomatic, she also had osteomyelitis in the sternocostoclavicular region, and was suspected of having synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome, against which minocycline showed marked efficacy. The presence of severe inflammatory SAPHO, albeit rare, together with the marked efficacy of tetracycline, should be noted.

• Authors: Yasunobu Takizawa, Atsuko Murota, Keigo Setoguchi, Yoshihisa Suzuki
• Journal: Modern rheumatology (Mod Rheumatol) Vol. 24 Issue 6 Pg. 1015-8 (Nov 2014) ISSN: 1439-7609 [Electronic] England
• PMID: 24533553 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Minocycline

Topics

• Acquired Hyperostosis Syndrome (complications, drug therapy)
• Anti-Inflammatory Agents (therapeutic use)
• Female
• Humans
• Inflammation (complications, drug therapy)
• Middle Aged
• Minocycline (therapeutic use)
• Treatment Outcome