Colchicine-responsive protracted gouty arthritis with systemic inflammatory reactions.

Abstract

Acute gouty arthritis is a severe but self-limiting arthritis caused by inflammatory responses to urate crystals. Oral colchicines are effective for initial stages or prophylaxis, but generally, colchicines are ineffective for established gouty arthritis. We describe an unusual case of gouty arthritis with systemic inflammatory reactions, including high fever and polymyalgia. Refractory polyarthritis and high fever were eradicated by colchicine treatment. Genetic analysis revealed a heterozygous mutation in exon 2 of the MEFV gene (E148Q). This case underscores the possibility that MEFV gene mutations may modify the phenotype of gouty arthritis.

• Authors: Fumiaki Nonaka, Kiyoshi Migita, Tomoko Haramura, Remi Sumiyoshi, Atsushi Kawakami, Katsumi Eguchi
• Journal: Modern rheumatology (Mod Rheumatol) Vol. 24 Issue 3 Pg. 540-3 (May 2014) ISSN: 1439-7609 [Electronic] England
• PMID: 24533551 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cytoskeletal Proteins
• Gout Suppressants
• MEFV protein, human
• Pyrin
• Colchicine

Topics

• Arthritis, Gouty (complications, drug therapy, genetics)
• Colchicine (therapeutic use)
• Cytoskeletal Proteins (genetics)
• Fever (complications, drug therapy, genetics)
• Gout Suppressants (therapeutic use)
• Humans
• Male
• Middle Aged
• Mutation
• Pyrin
• Treatment Outcome