Evaluation of the effects of methotrexate released from polymeric implants in solid Ehrlich tumor.

Abstract

In this study, the effects of the controlled and sustained release of methotrexate from poly(ɛ-caprolactone) implants were evaluated in the solid Ehrlich tumor. The drug locally leached from the implantable devices was capable of reducing the tumor growth and the necrotic areas of the tumor site. Furthermore, the methotrexate exerted its anti-tumor effect probably by the recruitment of neutrophils at the tumor site, which assisted in modulating the growth of the tumor. The polymeric implants containing methotrexate could be a chemotherapic alternative to treat locally solid tumors with lower systemic side effects.

• Authors: Adriana de Fátima Pereira, Vivian Mara da Costa, Millene Cristina Magalhães Santos, Rosy Iara Maciel de A Ribeiro, Ana Gabriela Silva, Flávia Carmo Horta Pinto, Paula Vieira Teixeira Vidigal, Gisele Rodrigues Da Silva
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 68 Issue 3 Pg. 365-8 (Apr 2014) ISSN: 1950-6007 [Electronic] France
• PMID: 24529847 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antimetabolites, Antineoplastic
• Drug Carriers
• Drug Implants
• Polyesters
• polycaprolactone
• Methotrexate

Topics

• Animals
• Antimetabolites, Antineoplastic (administration & dosage, adverse effects, therapeutic use)
• Body Weight (drug effects)
• Carcinoma, Ehrlich Tumor (drug therapy, metabolism, pathology)
• Cell Proliferation (drug effects)
• Drug Carriers (administration & dosage, adverse effects, chemistry)
• Drug Implants
• Female
• Immunohistochemistry
• Methotrexate (administration & dosage, adverse effects, therapeutic use)
• Mice
• Polyesters (administration & dosage, adverse effects, chemistry)