Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats.
Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF STUDY: To evaluate the antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis (SAT) in experimental type 2 diabetic mellitus (T2DM) rats. MATERIALS AND METHODS: Acute toxicity was studied in rats to determine the safe oral dose of SAT. Then, SAT was given orally to normal and streptozotocin- nicotinamide induced T2DM rats at 80, 160 and 320 mg/kg doses for a series of 28 days to determine the antihyperglycemic activity. Glibenclamide (600 μg/kg), a standard antidiabetic drug, was used as a positive control drug. At the end of treatment, biochemical parameters and antioxidant levels were measured to evaluate the hypolipidemic and antioxidant activities of SAT. RESULTS:
Oral administration of SAT did not exhibit toxicity and death at a dose not more than 2000 mg/kg. SAT dose-dependently improved the symptoms of polydipsia, polyuria, polyphagia and weight loss in diabetic rats. Compared with diabetic control group, administration of 320 mg/kg SAT resulted in significant (P<0.05) fall in the levels of fasting blood glucose, glycosylated hemoglobin, creatinine, urea, alanine transarninase, aspartate aminotransferase, total cholesterol, triglycerides, low density lipoprotein cholesterol and malondialdehyde, but significant (P<0.05) increase in the levels of serum insulin, superoxide dismutase and reduced glutathione. However, SAT did not have any effect on the normal rats. CONCLUSIONS:
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Authors | Yan Weng, Lu Yu, Jia Cui, Yan-Rong Zhu, Chao Guo, Guo Wei, Jia-Lin Duan, Ying Yin, Yue Guan, Yan-Hua Wang, Zhi-Fu Yang, Miao-Miao Xi, Ai-Dong Wen |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 152
Issue 3
Pg. 553-60
(Mar 28 2014)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 24524879
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antioxidants
- Blood Glucose
- Hypoglycemic Agents
- Hypolipidemic Agents
- Lipids
- Plant Extracts
- Saponins
- Niacinamide
- Streptozocin
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Topics |
- Animals
- Antioxidants
(administration & dosage, isolation & purification, pharmacology)
- Aralia
(chemistry)
- Blood Glucose
(drug effects)
- Diabetes Mellitus, Experimental
(drug therapy, physiopathology)
- Diabetes Mellitus, Type 2
(drug therapy, physiopathology)
- Dose-Response Relationship, Drug
- Hypoglycemic Agents
(administration & dosage, isolation & purification, pharmacology)
- Hypolipidemic Agents
(administration & dosage, isolation & purification, pharmacology)
- Lipids
(blood)
- Male
- Niacinamide
(toxicity)
- Plant Extracts
(administration & dosage, pharmacology)
- Rats
- Rats, Wistar
- Saponins
(administration & dosage, isolation & purification, pharmacology)
- Streptozocin
(toxicity)
- Toxicity Tests, Acute
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