Chorioamnionitis in the pathogenesis of brain injury in preterm infants.

Abstract

Chorioamnionitis (or placental infection) is suspected to be a risk factor for brain injury in premature infants. The suggested association between chorioamnionitis and cystic periventricular leukomalacia and cerebral palsy is uncertain because of the variability of study designs and definitions of chorioamnionitis. Improvements in neonatal intensive care may have attenuated the impact of chorioamnionitis on brain health outcomes. Large multicenter studies using rigorous definitions of chorioamnionitis on placental pathologies and quantitative magnetic resonance techniques may offer the optimal way to clarify the complex role of chorioamnionitis in modifying brain health and long-term outcomes.

• Authors: Vann Chau, Deborah E McFadden, Kenneth J Poskitt, Steven P Miller
• Journal: Clinics in perinatology (Clin Perinatol) Vol. 41 Issue 1 Pg. 83-103 (Mar 2014) ISSN: 1557-9840 [Electronic] United States
• PMID: 24524448 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Cytokines
• Inflammation Mediators

Topics

• Brain Injuries (etiology, immunology, physiopathology)
• Cerebral Palsy (etiology, immunology, physiopathology)
• Chorioamnionitis (immunology, physiopathology)
• Cytokines (immunology)
• Female
• Fetal Diseases (etiology, immunology, physiopathology)
• Humans
• Infant, Newborn
• Infant, Premature
• Inflammation Mediators (immunology)
• Leukomalacia, Periventricular (etiology, immunology, physiopathology)
• Nerve Fibers, Myelinated (immunology)
• Pregnancy
• Systemic Inflammatory Response Syndrome (etiology, immunology, physiopathology)