Abstract | OBJECTIVE: Osteoclasts are bone-resorbing multinucleated cells derived from the monocyte/macrophage lineage during normal and pathological bone turnover. Recently, several studies revealed that alpha-tocopheryl succinate (αTP-suc) have demonstrated potent anti- cancer activities in vitro and in vivo. However, the effects of αTP-suc on osteoclast formation and bone resorption remain unknown. Thus, in this study, we examined the effects of αTP-suc on osteoclast differentiation and bone resorbing activity in inflammatory bone loss model. METHODS: RESULTS: αTP-suc inhibits osteoclast formation in cocultures stimulated by IL-1 and decreased the level of expression of RANKL mRNA in osteoblasts. In addition, administered intraperitoneal injections of αTP-suc prevented IL-1-mediated osteoclast formation and bone loss in vivo. CONCLUSION: Our findings suggest that αTP-suc may have therapeutic value for treating and preventing bone-resorptive diseases, such as osteoporosis.
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Authors | Ha-Neui Kim, Jong-Ho Lee, Won Jong Jin, Zang Hee Lee |
Journal | Journal of bone metabolism
(J Bone Metab)
Vol. 19
Issue 2
Pg. 111-20
(Nov 2012)
ISSN: 2287-6375 [Print] Korea (South) |
PMID | 24524041
(Publication Type: Journal Article)
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