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Radiofrequency ablation versus antiarrhythmic medication for treatment of ventricular premature beats from the right ventricular outflow tract: prospective randomized study.

AbstractBACKGROUND:
The purpose of this study was to compare the efficacy of radiofrequency catheter ablation (RFCA) versus antiarrhythmic drugs (AADs) for treatment of patients with frequent ventricular premature beats (VPBs) originating from the right ventricular outflow tract (RVOT).
METHODS AND RESULTS:
A total of 330 eligible patients were included in the study and were randomly assigned to RFCA or AADs group. The absolute number and the burden of VPBs on 12-lead Holter monitors were measured at baseline and at 1st, 3rd, 6th, and 12th months after randomization. Left ventricular eject fraction was evaluated by transthoracic echocardiogram at baseline and at 3 and 6 months after randomization. During the 1-year follow-up period, VPB recurrence was significantly lower in patients randomized to RFCA group (32 patients, 19.4%) versus AADs group (146 patients, 88.6%; P<0.001, log-rank test). In a Poisson generalized estimating equations (GEE) regression model, RFCA was associated with a greater decrease in the burden of VPBs (incidence rate ratio 0.105; 95% confidence intervals [0.104-0.105]; P<0.001) compared with AADs. In a liner GEE model, the left ventricular eject fraction had a tendency to increase after the treatment in both groups (coefficient, 0.584; 95% confidence intervals [0.467-0.702]; P<0.001). In a Cox proportional model, the QS morphology in lead I was the only predictor of VPB recurrence free for catheter ablation (hazards ratio, 0.154; 95% confidence intervals [0.044-0.543]; P=0.004).
CONCLUSIONS:
Catheter ablation is more efficacious than AADs for preventing VPB recurrence in patients with frequent VPBs originating from the RVOT. QS morphology in lead I was associated with better outcome after ablation.
AuthorsZhiyu Ling, Zengzhang Liu, Li Su, Vadim Zipunnikov, Jinjin Wu, Huaan Du, Kamsang Woo, Shaojie Chen, Bin Zhong, Xianbin Lan, Jinqi Fan, Yanping Xu, Weijie Chen, Yuehui Yin, Saman Nazarian, Bernhard Zrenner
JournalCirculation. Arrhythmia and electrophysiology (Circ Arrhythm Electrophysiol) Vol. 7 Issue 2 Pg. 237-43 (Apr 2014) ISSN: 1941-3084 [Electronic] United States
PMID24523413 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Arrhythmia Agents
Topics
  • Anti-Arrhythmia Agents (therapeutic use)
  • Catheter Ablation (methods)
  • Echocardiography
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Heart Conduction System (physiopathology, surgery)
  • Heart Ventricles (physiopathology)
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Secondary Prevention
  • Stroke Volume
  • Treatment Outcome
  • Ventricular Function, Left (physiology)
  • Ventricular Premature Complexes (diagnosis, physiopathology, therapy)

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