Antiandrogen and
alpha-adrenergic blockers have recently been tried in the medical treatment for
benign prostatic hypertrophy and bladder neck
contracture. We herein report our results of a randomized comparative study on the clinical efficacy of
oxendolone,
bunazosin hydrochloride (
bunazosin) and their combination for the treatment of
benign prostatic hypertrophy and bladder neck
contracture. The attending doctors evaluated at twelve weeks the improvement rate for three treatment regimens, 400 mg/day
oxendolone, 3 mg/day
bunazosin and a combination of both.
Oxendolone +
bunazosin showed the highest improvement rate in the evaluation of each subjective symptom and objective finding and of both.
Oxendolone +
bunazosin tended to show a better clinical efficacy than the other of these regimens, when the improvement was defined as that with more than one degree in the severity of retarded voiding, prolonged voiding, urinary stream condition, abdominal pressure on voiding and residual urine sensation. The improvement of such subjective symptoms seemed to occur earlier with
oxendolone +
bunazosin or
bunazosin than with
oxendolone. A significant difference was shown among the three treatment regimens in the general improvement rate on four subjective symptoms, with
oxendolone +
bunazosin being the highest followed by
bunazosin and
oxendolone in this order. The improvement rates of maximum and mean flow rate which are most important parameters to evaluate the voiding condition, at twelve weeks were significantly higher with
oxendolone +
bunazosin. No serious side effects were observed in this study, although treatment regimens containing
bunazosin caused some minor side effects. These side effects could be prevented by the use of initial low doses of
bunazosin with a subsequent gradual increment up to 3 mg/day. Taking the differences in the mechanism of
oxendolone and
bunazosin and the results of our study into consideration, we believe that the combination of
oxendolone and
bunazosin would be more useful in a clinical situation.