The history of
haemophilia dates back to the 2nd century AD, with the first "modern" descriptions of the condition appearing during the 1800s. At that time, transfusion medicine and
haemophilia became closely linked, with
blood transfusion being the only possible treatment option. A turning point in the history of
haemophilia came in the middle of the 20th century when researchers identified an "antihaemophilic
globulin" that could reduce the clotting time in haemophilic blood, thereby paving the way for the introduction of cryoprecipitate and the first
clotting factor concentrates for the treatment of
haemophilia A,
haemophilia B and
von Willebrand disease. The availability of pasteurized, and therefore virus-safe, plasma-derived,
clotting factor concentrates, such as
Haemate P(®) and Beriate(®) P in Germany and other countries, dramatically improved the quality of life and life expectancy of
haemophilia patients. These and other treatment advances enabled home treatment, with many centres introducing prophylaxis to younger patients. Today, thanks to the support from patient organizations, such as the German
Haemophilia Society, which was founded by Prof. Rudolf Marx from Munich,
haemophilia patients can be assured of good
bleeding control using products with established efficacy and safety profiles. Work on improving factor concentrates continues, with efforts directed towards extending their half-lives using recombinant
albumin-fused
proteins and other modern technologies. The past 20 years has witnessed major improvements in almost all aspects of
haemophilia treatment. It is hoped the next 20 years will add promising new chapters to the
haemophilia book of history.