Split-dose cisplatin and vinorelbine as adjuvant chemotherapy for completely resected non-small cell lung cancer.

Abstract

AIM:

The aim of the present study was to evaluate the feasibility of, and compliance with a regimen using split-dose cisplatin and vinorelbine (split-CV) as adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC).

PATIENTS AND METHODS:

The treatment schedule included cisplatin at 40 mg/m(2) and vinorelbine at 25 mg/m(2) administered intravenously on days 1 and 8, every three weeks for four cycles.

RESULTS:

This study included 22 patients (male/female; 12/10) with a median age of 67 (range 50-76) years; 10 had clinical stage II and 12 stage III; 21 had ECOG 0 and 1 patient ECOG 1; 15 patients had adenocarcinoma, 5 squamous cell and 2 adenosquamous carcinoma; 18 patients had undergone lobectomy, 3 pneumonectomy and 1 segmentectomy. Seventeen out of 22 patients (77%) received the planned 4 cycles. The main adverse events were grade 3/4 neutropenia (76%) and anemia (12%). The average total doses of cisplatin and vinorelbine were 285 mg/m(2) and 177 mg/m(2), respectively.

CONCLUSION:

The split-CV regimen is well-tolerated as adjuvant chemotherapy for completely resected NSCLC.

• Authors: Fumihiko Hirai, Takashi Seto, Mototsugu Shimokawa, Eiko Inamasu, Ryo Toyozawa, Gouji Toyokawa, Tsukihisa Yoshida, Yoshimasa Shiraishi, Tomoyoshi Takenaka, Masafumi Yamaguchi, Mitsuhiro Takenoyama, Yukito Ichinose
• Journal: Anticancer research (Anticancer Res) Vol. 34 Issue 2 Pg. 927-31 (Feb 2014) ISSN: 1791-7530 [Electronic] Greece
• PMID: 24511034 (Publication Type: Journal Article)

Chemical References

• Vinblastine
• Cisplatin
• Vinorelbine

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Carcinoma, Non-Small-Cell Lung (diagnostic imaging, drug therapy, pathology)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage, adverse effects)
• Disease-Free Survival
• Drug Administration Schedule
• Female
• Humans
• Kaplan-Meier Estimate
• Lung Neoplasms (drug therapy, pathology, surgery)
• Male
• Medication Adherence
• Middle Aged
• Neoplasm Staging
• Retrospective Studies
• Ultrasonography
• Vinblastine (administration & dosage, adverse effects, analogs & derivatives)
• Vinorelbine