Delayed hypersensitivity reaction after initial dose of infliximab: a case report.

Abstract

We report here an unusual case of delayed hypersensitivity reaction in a young woman with ulcerative colitis after the first administration of infliximab (IFX). The patient developed severe serum-sickness-like reaction, and her anti-IFX antibody titer increased rapidly after a single infusion of IFX. The possible reason for the delayed hypersensitivity reaction to a single IFX exposure might be the presensitization of the patient by murine antigens as she had been keeping mice and hamsters as pets for several years.

• Authors: Anna Krajcovicova, Tibor Hlavaty, Zuzana Zelinkova, Juraj Letkovsky, Martin Huorka
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 26 Issue 4 Pg. 485-7 (Apr 2014) ISSN: 1473-5687 [Electronic] England
• PMID: 24509644 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antibodies
• Antibodies, Monoclonal
• Gastrointestinal Agents
• Infliximab

Topics

• Animals
• Anti-Inflammatory Agents (adverse effects, immunology)
• Antibodies (blood)
• Antibodies, Monoclonal (adverse effects, immunology)
• Colitis, Ulcerative (drug therapy)
• Cricetinae (immunology)
• Drug Hypersensitivity (blood, diagnosis, etiology, immunology)
• Drug Substitution
• Female
• Gastrointestinal Agents (adverse effects, immunology)
• Humans
• Hypersensitivity, Delayed (blood, chemically induced, diagnosis, immunology)
• Infliximab
• Mice (immunology)
• Pets (immunology)
• Risk Factors
• Young Adult