Neuropsychological functioning in youth with obsessive compulsive disorder: an examination of executive function and memory impairment.

Abstract

Preliminary research suggests neuropsychological deficits in youth with obsessive-compulsive disorder (OCD) similar to those in adults; however, small samples and methodological confounds limit interpretation. We aimed to examine the rates and clinical correlates of cognitive sequelae in youth with OCD, focusing on executive functioning and memory abilities. Youth ages 7-17 years with OCD (N=96) completed a hypothesis-driven neuropsychological battery (including the Rey-Osterreith Complex Figure, California Verbal Learning Test, and subtests of the Delis-Kaplan Executive Function System and Wide Range Assessment of Memory and Learning) that primarily assessed executive functioning, memory and processing speed. Cognitive sequelae were identified in 65% of youth (37% using a more stringent definition of impairment). Magnitude of cognitive sequelae was not associated with OCD severity or age; however, greater neuropsychological impairments were found amongst youth prescribed atypical neuroleptics and those diagnosed with comorbid tic disorders. Comorbidity burden was associated with presence of neuropsychological impairment, but was not specific to any single test. Findings suggest that the presence of cognitive sequelae is prevalent amongst treatment-seeking youth with OCD. Deficits were found in executive functioning and non-verbal memory performance but these impairments were not associated with OCD severity.

• Authors: Adam B Lewin, Michael J Larson, Jennifer M Park, Joseph F McGuire, Tanya K Murphy, Eric A Storch
• Journal: Psychiatry research (Psychiatry Res) Vol. 216 Issue 1 Pg. 108-15 (Apr 30 2014) ISSN: 1872-7123 [Electronic] Ireland
• PMID: 24508366 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antipsychotic Agents

Topics

• Adolescent
• Antipsychotic Agents (therapeutic use)
• Case-Control Studies
• Child
• Executive Function
• Female
• Humans
• Male
• Memory
• Neuropsychological Tests
• Obsessive-Compulsive Disorder (complications, drug therapy, psychology)
• Severity of Illness Index