Abstract | BACKGROUND AND AIMS: METHODS: Data were analyzed from 14,584 Korean subjects. Subjects were stratified according to: a) 6030 (41.3%) patients with normal blood pressure (<120/80 mmHg), b) 5630 (38.6%) patients with pre-hypertension (120-139 mmHg and 80-89 mmHg) and c) 2924 (20.0%) patients with hypertension (≥140/90 mmHg). Prevalence and odds ratio for the association between increased hs-CRP (>2 mg/L) and presence of CAC (coronary artery calcium) were calculated. RESULTS: In both normal and pre-hypertensive groups, the prevalence of CAC >0 was higher in subjects with increased hs-CRP concentrations (>2 mg/L). Adjusting for age, sex, cerebrovascular accident, coronary heart disease and diabetes mellitus, lifestyle, obesity, fasting glucose, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol concentrations, there was a significant association between higher hs-CRP levels (>2 mg/L) and CAC score in the normal group (OR 1.55, 95% CI 1.11-2.16; p = 0.010); a borderline significant association in the pre-hypertensive group (OR 1.33, 95% CI 0.99-1.76; p = 0.054); and no association in the hypertensive group (OR 1.01, 95% CI 0.76-1.33; p = 0.94). CONCLUSIONS:
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Authors | Joo-Wook Sung, Sung Ho Lee, Christopher D Byrne, Pil-Wook Chung, Yu Sam Won, Ki-Chul Sung |
Journal | Archives of medical research
(Arch Med Res)
Vol. 45
Issue 2
Pg. 170-6
(Feb 2014)
ISSN: 1873-5487 [Electronic] United States |
PMID | 24508289
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 IMSS. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- C-Reactive Protein
- Calcium
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Topics |
- Atherosclerosis
(metabolism)
- Biomarkers
(metabolism)
- Blood Pressure
- C-Reactive Protein
(metabolism)
- Calcium
(metabolism)
- Coronary Vessels
(metabolism)
- Female
- Humans
- Hypertension
(metabolism, physiopathology)
- Male
- Middle Aged
- Risk Factors
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