[Concepts in the prevention and treatment of liver metastases of colorectal cancer by regional chemotherapy].

Abstract

Three different treatments of regional chemotherapy in colo-rectal malignancies and their results are presented. 1. Prophylactic chemotherapy with 5-FU--via the recanalized umbilical vein in patients without liver metastases (randomized study since 10/1980). 2. Intraportal adjuvant chemotherapy after resection of liver metastases. 3. Intraarterial chemotherapy in patients with unresectable liver metastases. The regional chemotherapy of the liver in colo-rectal diseases seems to increase the survival rate and the quality of life. The Port-A-Cath-system can be used repeatedly, however, there is a certain rate of complications to be expected.

• Authors: E Molzahn, H H Gruenagel, U Freund, D Gross
• Journal: Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen (Chirurg) Vol. 59 Issue 1 Pg. 34-40 (Jan 1988) ISSN: 0009-4722 [Print] Germany
• Vernacular Title: Konzepte zur Prophylaxe und Behandlung von Lebermetastasen beim colorectalen Carcinom durch regionale Chemotherapie.
• PMID: 2450722 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Mitomycins
• Mitomycin
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Cancer, Regional Perfusion
• Colonic Neoplasms (drug therapy)
• Fluorouracil (administration & dosage)
• Follow-Up Studies
• Humans
• Infusions, Intra-Arterial
• Liver Neoplasms (drug therapy, secondary)
• Mitomycin
• Mitomycins (administration & dosage)
• Palliative Care
• Rectal Neoplasms (drug therapy)