Abstract | BACKGROUND: OBJECTIVE AND METHODS: A meta-analysis was conducted to investigate the association between eNOS G894T polymorphism and MI. Published studies from PubMed, Embase, CNKI and CBM databases were retrieved. The pooled odds ratios ( ORs) for the association between eNOS G894T polymorphism and MI and their corresponding 95% confidence intervals (CIs) were estimated using the random- or fixed- effect model. RESULTS: A total of 34 studies including 8229 cases and 12839 controls were identified for the meta-analysis. The eNOS G894T polymorphism was significantly associated with MI under a homozygous genetic model (OR = 1.41, 95% CI = 1.08-1.84; P = 0.012), a recessive genetic model (OR = 1.35, 95% CI = 1.06-1.70; P = 0.014), a dominant genetic model (OR = 1.18, 95% CI = 1.04-1.34; P = 0.009). In the subgroup analysis by ethnicity (non-Asian and Asian), no significant association was observed between eNOS G894T polymorphism and MI risk among non-Asians (P>0.05), but a positive significant association was found among Asians (P<0.05). CONCLUSIONS: The eNOS G894T polymorphism is associated with increased MI risk in Asians. The results indicate that ethnicity plays important roles in the association between eNOS G894T polymorphism and MI.
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Authors | Jian-Quan Luo, Jia-Gen Wen, Hong-Hao Zhou, Xiao-Ping Chen, Wei Zhang |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 1
Pg. e87196
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24498040
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- NOS3 protein, human
- Nitric Oxide Synthase Type III
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Topics |
- Asian People
(genetics)
- Case-Control Studies
- Genetic Predisposition to Disease
(genetics)
- Genotype
- Humans
- Myocardial Infarction
(etiology, genetics)
- Nitric Oxide Synthase Type III
(genetics)
- Polymorphism, Genetic
(genetics)
- Risk
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