The relation of plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) with HPV persistence in HIV-infected and HIV-uninfected women.

Abstract

Other than CD4+ count, the immunologic factors that underlie the relationship of HIV/AIDS with persistent oncogenic HPV (oncHPV) and cervical cancer are not well understood. Plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) are of particular interest. pDCs have both effector and antigen presenting activity and, in HIV-positive patients, low pDC levels are associated with opportunistic infections. Tregs downregulate immune responses, and are present at high levels in HIV-positives. The current pilot study shows for the first time that low pDC and high Treg levels may be significantly associated with oncHPV persistence in both HIV-positive and HIV-negative women. Larger studies are now warranted.

• Authors: Howard D Strickler, Jeffrey Martinson, Seema Desai, Xianhong Xie, Robert D Burk, Kathryn Anastos, L Stewart Massad, Howard Minkoff, Xiaonan Xue, Gypsyamber D'Souza, Alexandra M Levine, Christine Colie, D Heather Watts, Joel M Palefsky, Alan Landay
• Journal: Viral immunology (Viral Immunol) Vol. 27 Issue 1 Pg. 20-5 (Feb 2014) ISSN: 1557-8976 [Electronic] United States
• PMID: 24494969 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Topics

• Adult
• CD4 Lymphocyte Count
• CD4-Positive T-Lymphocytes (immunology)
• Chronic Disease
• Dendritic Cells (immunology)
• Female
• HIV Infections (complications, immunology, virology)
• Humans
• Papillomavirus Infections (immunology, virology)
• Pilot Projects
• T-Lymphocytes, Regulatory (immunology)
• Uterine Cervical Neoplasms (immunology, virology)