Detection of antibodies to human T-cell leukemia virus types 1 and 2 in breast milk from East Asian women.
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| Abstract |
We investigated the incidence of human T-cell leukemia virus type I (HTLV-1) infection in a total of 17 regions in four countries, including 13 regions in Japan, as well as Korea (Seoul and Busan), China, and Vietnam, by testing breast milk using a particle agglutination assay (PA) and line immunoassay (LIA). Among 266 samples from Japan, 24 (9.0%) were positive on PA and 3 (1.1%) were positive on LIA. Among 50 samples from Seoul, 2 were positive on PA and 1 was positive on LIA. In contrast, all 50 samples from Busan were negative on both tests, suggesting the maldistribution of HTLV-1 infectants in South Korea. The numbers of positive samples were 2/91 on PA and 1/91 on LIA for China and 1/88 on both PA and LIA for Vietnam. In China, one sample with a high probability of HTLV-2 infection was identified by LIA and synthetic peptide enzyme-linked immunosorbent assay (ELISA). We examined HTLV-1 antibody in breast milk samples using commercially available test kits, suggesting the existence of HTLV-1 carriers in endemic areas in Southeast Asia and an HTLV-2 infectant in China. As a part of human ethno-epidemiological research, these results constitute valuable epidemiological data. Further studies on the sensitivity, specificity, and reliability of assays using antibodies to HTLV-1 and 2 in breast milk will be necessary for large-scale epidemiological surveys of HTLV infection.
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| Authors | Futoshi Matsubara, Yasuko Sagara, Yoshihisa Kato, Kouji Harada, Akio Koizumi, Koichi Haraguchi |
| Journal | Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 37 Issue 2 Pg. 311-4 ( 2014) ISSN: 1347-5215 [Electronic] Japan |
| PMID | 24492727 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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