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Intra-tumor distribution of metallofullerene using micro-particle induced X-ray emission (PIXE).

Abstract
To clarify the intra tumor distribution of gadlinium containing fullerene (Gd@C82), micro particle induced X-ray emission (Micro-PIXE) analysis were performed. The tumor bearing BALB/c mice were injected Gd@C82 and subcutaneous tumors were taken from 48h after the intravenous injection. Using the Micro-PIXE method, we could visualize Gd intra tumor distribution. Therefore our results indicate the possibility that Micro-PIXE is useful technique for imaging the bioditribution of Gd, and Gd@C82 is potentially useful Gd carrier for NCT.
AuthorsYohei Yamamoto, Tetsuya Yamamoto, Yukichi Horiguchi, Makoto Shirakawa, Takahiro Satoh, Masashi Koka, Yukio Nagasaki, Kei Nakai, Akira Matsumura
JournalApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 88 Pg. 114-7 (Jun 2014) ISSN: 1872-9800 [Electronic] England
PMID24491681 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014. Published by Elsevier Ltd.
Chemical References
  • Fullerenes
  • Gadolinium
Topics
  • Animals
  • Cell Line, Tumor
  • Colonic Neoplasms (chemistry, pathology)
  • Fullerenes (chemistry, therapeutic use)
  • Gadolinium (chemistry, therapeutic use)
  • Mice
  • Mice, Inbred BALB C
  • Microspheres
  • Spectrometry, X-Ray Emission (methods)

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