Abstract |
To clarify the intra tumor distribution of gadlinium containing fullerene (Gd@C82), micro particle induced X-ray emission (Micro-PIXE) analysis were performed. The tumor bearing BALB/c mice were injected Gd@C82 and subcutaneous tumors were taken from 48h after the intravenous injection. Using the Micro-PIXE method, we could visualize Gd intra tumor distribution. Therefore our results indicate the possibility that Micro-PIXE is useful technique for imaging the bioditribution of Gd, and Gd@C82 is potentially useful Gd carrier for NCT.
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Authors | Yohei Yamamoto, Tetsuya Yamamoto, Yukichi Horiguchi, Makoto Shirakawa, Takahiro Satoh, Masashi Koka, Yukio Nagasaki, Kei Nakai, Akira Matsumura |
Journal | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
(Appl Radiat Isot)
Vol. 88
Pg. 114-7
(Jun 2014)
ISSN: 1872-9800 [Electronic] England |
PMID | 24491681
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014. Published by Elsevier Ltd. |
Chemical References |
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Topics |
- Animals
- Cell Line, Tumor
- Colonic Neoplasms
(chemistry, pathology)
- Fullerenes
(chemistry, therapeutic use)
- Gadolinium
(chemistry, therapeutic use)
- Mice
- Mice, Inbred BALB C
- Microspheres
- Spectrometry, X-Ray Emission
(methods)
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