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The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma.

Abstract
Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16(INK4a), p14(ARF), NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.
AuthorsLeonardo Vinícius Monteiro de Assis, Jamille Locatelli, Mauro César Isoldi
JournalBiochimica et biophysica acta (Biochim Biophys Acta) Vol. 1845 Issue 2 Pg. 232-47 (Apr 2014) ISSN: 0006-3002 [Print] Netherlands
PMID24491449 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • erionite
  • Zeolites
  • Asbestos
Topics
  • Asbestos (toxicity)
  • Carcinogenesis (genetics)
  • Cell Transformation, Neoplastic (genetics, pathology)
  • Humans
  • Lung Neoplasms (etiology, genetics, pathology)
  • Mesothelioma (etiology, genetics, pathology)
  • Mesothelioma, Malignant
  • Phosphatidylinositol 3-Kinases (genetics, metabolism)
  • Signal Transduction (genetics)
  • Simian virus 40 (pathogenicity)
  • Zeolites (toxicity)

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