Lack of selective vulnerability to anticholinergic induced cognitive impairment in early Parkinson's disease.

Abstract

Thirteen patients with idiopathic Parkinson's disease of recent onset (mean age 63·2 years) and a group of 10 young healthy volunteers (mean age 26·1 years) underwent a series of neuropsychological tests for assessment of memory, learning ability and mental processing speed before and during treatment with trihexyphenidyl. Retesting after anticholinergic exposure (mean of 2 weeks for patients and 1 week for controls) revealed in young healthy controls the same pattern and magnitude of decline in memory function as in Parkinson patients. Non-demented subjects with Parkinson's disease of recent onset thus do riot seem to be selectively vulnerable to cognitive side-effects of anticholinergic treatment.

• Authors: L Schelosky, T Benke, W Poewe
• Journal: Behavioural neurology (Behav Neurol) Vol. 4 Issue 2 Pg. 103-11 ( 1991) ISSN: 0953-4180 [Print] Netherlands
• PMID: 24487440 (Publication Type: Journal Article)