Serological diagnosis with recombinant N antigen for hantavirus infection.

Abstract

Hantaviruses are causative agents of two rodent-borne zoonoses, hemorrhagic fever with renal syndrome (HFRS) and nephropathia epidemica (NE) in the Old World and hantavirus pulmonary syndrome (HPS) in the New World. Serological examinations to detect hantavirus antibodies have been most widely used for surveillance among humans and rodent reservoirs. Here, we will review antigenic structure of nucleocapsid (N) protein of hantaviruses and application of recombinant N protein as diagnostic antigen for screening and serotyping.

• Authors: Kumiko Yoshimatsu, Jiro Arikawa
• Journal: Virus research (Virus Res) Vol. 187 Pg. 77-83 (Jul 17 2014) ISSN: 1872-7492 [Electronic] Netherlands
• PMID: 24487183 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

Chemical References

• Antibodies, Viral
• Antigens, Viral
• Capsid Proteins
• Recombinant Proteins
• Viral Core Proteins
• nucleocapsid protein, Hantaan virus

Topics

• Animals
• Antibodies, Viral (blood)
• Antigens, Viral (blood)
• Capsid Proteins (chemistry, genetics, immunology)
• Chromatography, Affinity
• Escherichia coli (genetics, metabolism)
• Gene Expression
• Orthohantavirus (classification, genetics, immunology)
• Hantavirus Infections (blood, diagnosis, immunology, virology)
• Humans
• Neutralization Tests
• Phylogeny
• Recombinant Proteins (chemistry, genetics, immunology)
• Viral Core Proteins (chemistry, genetics, immunology)