Abstract | BACKGROUND: Antibody deficiency comprises a heterogeneous group of disorders characterised by the body's inability to mount an effective antibody response to pathogens. Although it has been reported that asthma and allergic disease are frequent in antibody deficiencies, there are no data that evaluate and compare bronchial hyperreactivity (BHR) in all groups of antibody deficiencies. In this study, we aimed to evaluate and compare the frequency of BHR in patients with different antibody deficiencies. METHODS: The study was carried out on 113 patients between ages 5 and 18 diagnosed with antibody deficiencies. The patients and their families were questioned on their history of asthma and allergic diseases. Allergic skin prick tests and non-specific bronchial provocation test with methacholine was done for all patients. Complete blood count and serum total IgE levels were measured. RESULTS: CONCLUSION: BHR was high in antibody deficiencies, especially selective IgA deficiency compared to IgG subclass deficiency.
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Authors | Celal Özcan, Ayşe Metin, Mustafa Erkoçoğlu, Can Naci Kocabas |
Journal | Allergologia et immunopathologia
(Allergol Immunopathol (Madr))
2015 Jan-Feb
Vol. 43
Issue 1
Pg. 57-61
ISSN: 1578-1267 [Electronic] Singapore |
PMID | 24485938
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 SEICAP. Published by Elsevier Espana. All rights reserved. |
Chemical References |
- Allergens
- Antibodies
- Immunoglobulin E
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Topics |
- Adolescent
- Allergens
(immunology)
- Antibodies
(genetics)
- Blood Cell Count
- Bronchial Hyperreactivity
(epidemiology)
- Bronchial Provocation Tests
- Child
- Child, Preschool
- Female
- Humans
- Hypersensitivity
(epidemiology)
- IgA Deficiency
(epidemiology)
- Immunoglobulin E
(blood)
- Immunologic Deficiency Syndromes
(epidemiology)
- Incidence
- Male
- Skin Tests
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